Neo-Predef with Tetracaine Powder
Delivers the therapeutic benefit of a topical antibiotic, anti-inflammatory, and anesthetic
NEO-PREDEF with Tetracaine Powder is indicated in the treatment or adjunctive therapy of certain ear and skin conditions—in dogs, cats and horses—caused by or associated with neomycin susceptible organisms and/or allergy. In addition, it is indicated as superficial dressing applied to minor cuts, wounds, lacerations and abrasions, and for postsurgical application where reduction of pain and inflammatory response is deemed desirable.
Applied superficially, it has been used successfully in the treatment of acute otitis externa, acute moist dermatitis and interdigitial dermatitis in dogs, and as a dusting powder to various minor cuts, lacerations, and abrasions in the horse, cat and dog.
Key Benefits
- 3-way therapy provides an antibiotic, anti-inflammatory, and anesthetic effect.
- Isoflupredone has potent anti-inflammatory action.
- Neomycin has a broad spectrum of antibacterial activity.
- Tetracaine provides rapid, potent topical anesthesia that can reduce the possibility of self-inflicted trauma.
- Prompt relief of symptoms.
- Reduces further self-inflicted trauma.
- Ease of application.
- Adherent to moist surfaces.
Important Safety Information
Prior to administering NEO-PREDEF with Tetracaine, ensure tympanic membrane is not ruptured. If hearing or vestibular dysfunction is noted during the course of treatment, discontinue use. Observe treated animals for signs of hypersensitivity or allergy and discontinue use if noted. See full Prescribing Information.
ISOFLUPREDONE ACETATE
Isoflupredone acetate markedly inhibits inflammatory reaction through its controlling influence on connective tissue and vascular components. Topically applied isoflupredone acetate is usually rapidly effective. In otitis externa, wounds of the concha, ulcerations of the ear flaps, and irritated lesions of the skin, the inflammatory response may also be effectively inhibited by isoflupredone acetate. Chronic conditions respond more slowly and relapses are more frequent.
NEOMYCIN
Neomycin is an antibiotic substance derived from cultures of the soil organism Streptomyces fradiae. Its antimicrobial range includes both gram-positive and gram-negative organisms commonly responsible for or associated with otic infections, such as staphylococci, streptococci, Escherichia coli., Aerobacter aerogenes, and many strains of Proteus and Pseudomonas organisms. It is not active against fungi. Neomycin is unusually nontoxic for epithelial cells in tissue culture and is nonirritating in therapeutic concentrations. The presence of neomycin in NEO-PREDEF with Tetracaine Powder affords control of neomycin-sensitive organisms.
TETRACAINE
Tetracaine hydrochloride is a topical anesthetic agent that is more potent than either procaine or cocaine in comparable concentration. The duration of anesthetic action of tetracaine exceeds that produced by either butacaine or phenacaine.
Many investigators have demonstrated that local anesthesia plays a significant part in the promotion of healing, especially where pain is a prominent factor. It is believed that trauma stimulates local pain receptors, which results in reflex vasodilation, edema, tenderness, and muscular spasm.
If the reflex is abolished through use of a local anesthetic such as tetracaine, amelioration of these tissue changes that interfere with healing is favored. The local anesthetic action of tetracaine has proved to be of great value in alleviating the pain reflex in painful skin and ear conditions.
After cleansing the affected area, NEO-PREDEF with Tetracaine Powder is applied by compressing the sides of the container with short, sharp squeezes. In most instances a single daily application will be sufficient; however, it may be applied one to three times daily, as required.
Because of the hygroscopic properties of neomycin sulfate, this bottle should be stored in a dry place. The cap should be replaced when the bottle is not in use. This puffer bottle has been designed to permit dusting when held in any position. Protecting the outlet from moisture will aid in assuring proper function; therefore, the tip should not be allowed to come in contact with moist membranes or weeping surfaces.
Please refer to the full Prescribing Information for complete dosage and administration.